Abstract
Activation of plasma proteins and cells in the idiopathic respiratory distress syndrome may be influenced by gestational age. We measured in plasma complement hemolytic activity (CH50), and activation of leukocytes (beta-glucuronidase, BG) and clotting (fibrin monomers, FM) in preterm ventilated rabbits of 28d and 29d of gestational age. Dynamic lung compliance (Cdyn) and ventilatory efficiency index (VEI) served as lung function parameters.
Conclusion: Decreased Cdyn and VEI in preterm ventilated rabbits of shorter gestational age are associated with increased systemic activation of complement, leukocytes, and clotting. This systemic activation process may contribute to further lung injury.
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Brus, F., Van Oeveren, W., Heykamp, A. et al. 35 SHORTER GESTATIONAL AGE IS ASSOCIATED WITH SYSTEMIC ACTIVATION OF COMPLEMENT, LEUKOCYTES AND CLOTTING IN PRETERM VENTILATED RABBITS. Pediatr Res 36, 8 (1994). https://doi.org/10.1203/00006450-199407000-00035
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DOI: https://doi.org/10.1203/00006450-199407000-00035