Abstract
Data on the antioxidant properties of B-carotcne (BC) in humans is limited. To answer the question if vitamin P sufficient CP patients with BC deficiency exhibit increased formation of lipid peroxides and if correction of this deficiency does result in enhanced protection against lipid peioxidation, malondialdehyde-thiobarbituric acid (MDA-TBA) adduct (Wong et al) was quantitated along with a-tocopherol (AT) and BC in plasma of 31 CF patients before and after oral BC supplementation and in 40 controls.
CONCLUSIONS: Correction of BC deficiency in CF patients normalizes enhanced formation of lipid peroxidation products, which are proposed to exert toxic properties to proteins, DNA and other biomolecules.
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Winklhofer-Roob, B., Khoschosorur, G., Schmerling, D. et al. BETA-CAROTENE NORMALIZES ENHANCED LIPID PEROXIDE FORMATION IN CYSTIC FIBROSIS (CF) PATIENTS. Pediatr Res 35, 283 (1994). https://doi.org/10.1203/00006450-199402000-00171
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DOI: https://doi.org/10.1203/00006450-199402000-00171