Abstract
28 term newborns (GA 38-42 weeks) were studied. 9 were small for gestational age (SGA), 6 were large and the rest were appropriate. There was no correlation of IGFs or IGFBPs with gestational age. The relationship with birth weight (BW), placental weight (PW) and ponderal index (PI) were analyzed by linear regression. In the table
These findings support the hypothesis that IGFs and IGFBPs are involved in fetal and placental growth, and suggest that IGF-I and IGFBP-3 are regulated in a coordinated manner during the third trimester of pregnancy and divergent roles for the IGFBPs during fetal adaptation to intrauterine growth restriction.
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Osorio, M., Torres, J., Moya, F. et al. INSULIN-LIKE GROWTH FACTORS (IGF) AND THEIR BINDING PROTEINS IN CORD SERA OF CHILEAN NEWBORNS: RELATIONSHIP TO FETAL AND PLACENTAL GROWTH.. Pediatr Res 33, 662 (1993). https://doi.org/10.1203/00006450-199306000-00044
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DOI: https://doi.org/10.1203/00006450-199306000-00044