Abstract
We studied 114 girls with Turner syndrome aged from newborn to 30 years old. We observed spontaneous pubertal development and correlation with karyotype, statural growth and bone mineralization. 15% of the patients presented spontaneous telarche, 5% (6 girls) had spontaneous menarche at a mean age of 12 years. One of these patients had stopped menses after 7 years, another one presented oligomenorrhoea. 76% of these patients were above 50% percentile for age following Ranke chart. 23,5% of the patients with spontaneous pubertal development had 45 XO karyotype. Bone mineralization was lower than normal values in all patients with spontaneous pubertal development. There were no correlation between pelvic ultrasonography and clinical signs of pubertal development.
We conclude that clinical features are actually the best criteria to start substitute therapy.
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Russo, G., Nizzoli, G., Basso, S. et al. SPONTANEOUS PUBERTAL DEVELOPMENT IN TURNER SYNDROME. Pediatr Res 33 (Suppl 5), S89 (1993). https://doi.org/10.1203/00006450-199305001-00514
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DOI: https://doi.org/10.1203/00006450-199305001-00514