Abstract
Although exogenous esfrogens stimulate SHBG synthesis in vivo and in vitro, the effect of endogenous estradiol (E2) secretion on SHBG in female puberty is unknown, due to the confounding age-related decline of serum SHBG levels. The increased E2 secretion associated wtth CPP, and its suppression by GnRH agonists (GnRHa) provide a unique in vivo model to single out the effect of estrogens on SHBG. We thus measured serum SHBG (Farmos IRMA), LH (IRMA) and E2 (RIA) levels in 12 girls with CPP, Breast stage II-IV, before and during treatment (Tx) with depot leuprolide acetate (7.5 mg every 4 wks for 0.5-2.2 years); and in 12 age-matched, prepubertal girls. Values are MeanĀ±SD.
Thus, despite pubertal E2 concentrations, serum SHBG levels were not increased in CPP and were paradoxically lower than in controls. Moreover, SHBG levels were not modified by GnRHa-induced suppression of E2 secretion. These data suggest that estrogens, at the concentrations observed in early-mid puberty, do not participate in the regulation of serum SHBG levels.
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Garibaldi, L., Aceto, T., Weber, C. et al. SERUM SEX HORMONE BINDING GLOBULIN (SHBG) CONCENTRATIONS ARE NOT AFFECTED BY THE ESTROGEN MILIEU IN FEMALE CENTRAL PRECOCIOUS PUBERTY (CPP). Pediatr Res 33 (Suppl 5), S83 (1993). https://doi.org/10.1203/00006450-199305001-00481
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DOI: https://doi.org/10.1203/00006450-199305001-00481