Abstract
ICA have been tested in 13 390 unsclectcd school-children (age 6-17 yr) as part of a research program on risk factors for Type 1 diabetes in background populations. ICA were delected by the immuno-fluorcscence technique using a single human pancreas (limit of detection:4JDFu). The ovrall prevalence of ICA-positivity in these children from background population was 1.5%, and distributed as follows according to ICA litres : 28 sera were found with ICA ≥20 JDFu (0.2%) and 170 between 4-20 JDFu (1.3%), the majority of the sera were positive at the detection limit of the assay. The 2 groups of ICA + and - children did not significantly differ in term of age, distribution of fasting plasma glucose and family history of diabetes. There is a tendency, although not significant, for an increased frequency of HLA-alleles encoding for an amino-acid different from asparlic acid (NA) at the position 57 of the DQB chain in the children with high ICA litres in comparison to ICA-negative children :
132 (67%) ICA+ - children have been followed for a median duration of 22 mth. ICA litres were remarkably stable in the group with hihgh ICA litres, among whom one boy has become diabetic; among the remaining ICA+ children, 3 children converted into values >20 JDFu, and 15% became negative among whom 11 were previously measured at the detection limit. This study emphasizes that, given the low incidence of the disease in France, ICA would probably not be sufficient to predict the subsequent development of Type I diabetes in school-children.
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Levy-Marchal, C., Tichet, J., Fajardy, I. et al. FOLLOW-UP OF CHILDREN FROM BACKGROUND POPULATION WITH ISLET CELLS ANTIBODIES (ICA). Pediatr Res 33 (Suppl 5), S75 (1993). https://doi.org/10.1203/00006450-199305001-00434
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DOI: https://doi.org/10.1203/00006450-199305001-00434