Abstract
An open pilot trial of low dose cyclosporine was initiated in first degree relatives of type I diabetic children with the following criteria: age<12 years, HLA haploidentical or identical to the diabetic proband, ICA≥20 JDF units, first phase insulin response to glucose (1+3 minutes) repeatedly <40μU/ml, glucose intolerance according to NDDG criteria.
We conclude that cyciosporine can restore insulin secretion and glucose tolerance in preclinical diabetes. Failure in patient V.W. might be due to a long period of low insulin secretion prior to immunosuppression. The efficacy of this approach should be tested in a larger number of patients.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Carel, J., Bougnères, P. PRELIMINARY RESULTS OF A TRIAL OF LOW DOSE CYCLOSPORINE IN PRECLINICAL TYPE I DIABETES. Pediatr Res 33 (Suppl 5), S74 (1993). https://doi.org/10.1203/00006450-199305001-00427
Issue Date:
DOI: https://doi.org/10.1203/00006450-199305001-00427