Abstract
In order to determine immune and possibly non immune factors determining first phase insulin response to glucose (FPIRG) in siblings of type I diabetic patients, we performed a simplified intravenous glucose tolerance test in 170 normal children, 98 ICA negative and 12 ICA positive siblings of type I diabetic children. Normal children (age 3-16, 9.8±0.3 years) were patients hospitalized for reasons not interferring with glucose homeostasis and investigators' and colleagues' children. ICA negative siblings were similar to controls in respect to age (2-16, 9.3±0.4 years) and body mass index. Insulin was measured 1 and 3 minutes after i.v. injection of 0.5 mg/kg b.w. of 50% dextrose in 2.5 minutes. In normal children, FPIRG (1 + 3 minutes insulin measurements) increased with age, giving a linear regression curve of insulin 1 + 3 = 10.5*age + 11.3 (r=0.45). In comparison ICA negative siblings had a significantly lower FPIRG (86±6 vs 115±6 μU/ml, p<0.005). This difference was distributed evenly throughout the age range giving a linear regression curve of: insulin 1+3 = 4.6*age + 41 (r=0.3). None of the ICA negative siblings developped diabetes after a follow up of 4.5±1.1 years. ICA positive (≥20 JDF units) siblings had a FPIRG at first testing comprarable to that of ICA negative siblings (74±13 μU/ml, p<0.02 vs controls). Two of them became diabetic. We conclude that ICA negative siblings of diabetic patients have a decreased FPIRG. Further investigations are needed to elucidate the basis for this difference.
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Carel, J., Bougnères, P. DECREASED INSULIN RESPONSE TO GLUCOSE IN ISLET CELL ANTIBODY-NEGATIVE SIBLINGS OF TYPE I DIABETIC CHILDREN. Pediatr Res 33 (Suppl 5), S74 (1993). https://doi.org/10.1203/00006450-199305001-00426
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DOI: https://doi.org/10.1203/00006450-199305001-00426