Abstract
U-hGH was measured before and during IGF 1 therapy in 4 prepubertal children with LARON dwarfism, 2 boys and 2 girls, aged 4 to 14 years, severely growth retardated (− 4,5 SD to −5,5 SD).
Urine specimen were collected for 3 consecutive nights using plastic container after addition of BSA solution (30 % w/v) and u-hGH was measured using EIA commercial kit (NorditestR).
Results (mean of 3 u-hGH measurements) in ng/mmol of creatinine were:
Mean u-hGH (U) in untreated Laron dwarfism (U=6, 8) was as expected strongly higher than in normal prepubertal children (U=1, 63 ±0, 14 SD) and in other severe (<−3SD) growth retardations (U=2, 24 ± 0.32 SD). IGF 1 did not significantly decreased u-hGH excretion (U=6, 8 to 4, 6) nor plasma basal hGH secretion (mean 19.9 mUI/I to 20. 9 mUI/I). We concluded that u-hGH is of good predictive value for the diagnosis of LARON dwarfism but is not affected by IGF 1 therapy, despite growth acceleration. The role of IGF1 in the feed back regulation of GH secretion in Laron dwarfism remains questionnable.
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Lordereau-Richard, I., Georges, P. & Chaussain, J. U-hGH ASSAY IN LARON DWARFISM. Pediatr Res 33 (Suppl 5), S38 (1993). https://doi.org/10.1203/00006450-199305001-00210
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DOI: https://doi.org/10.1203/00006450-199305001-00210