Abstract
A double- blind, randomized trial was carried out, to evaluate the effects of prenatal administration of B and TRH on the incidence and severity of RDS. 57 premature infants (26-31 weeks of gestation) born from 52 mothers treated for 10 days prior to labor, were included. The study group (G1) (n=26) received B: 12mg IM q12 h plus TRH 200 ug IV q12 h. The control group (n=31) (G2) received an equal dose of B plus placebo. Incidence of RDS was 27% and 29% in G1 and G2, respectively. Significant differences were found in the duration of treatment with O2; x̄ 21 vs 108 h in G1 and G2, respectively (p= .004) and in the duration of IPPV x̄ 6.3 days in G2 vs 13.9 in G1 (p<0.05). Among there surviving beyond 28 days of life no infants in G1 received Fi02 > .21, while 6 (25%) in G2 required this treatment for a longer period (p= .02). No infants in G1 and 5 in G2 (21%) developed Bronchopulmonary displasia (BPD) (p= .02), Prenatal treatment with B plus TRH may be more efficient than B alone in reducing O2 requirements and the duration of oxygen therapy and mechanical ventilation. This therapy may diminish the incidence of BPD.
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Cernadas, J., Fustiñana, C., Althabe, F. et al. CONTROLLED TRIAL OF PRENATAL BETAMETHASONE (B) PLUS TRH FOR PREVENTION OF RESPIRATORY DISTRESS SYNDROME (RSD) IN PRETERM INFANTS. Pediatr Res 32, 738 (1992). https://doi.org/10.1203/00006450-199212000-00031
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DOI: https://doi.org/10.1203/00006450-199212000-00031
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