Abstract
Adult respiratory distress syndrome is associated with increased lung hyaluronan and water content (Am Rev Resp Dis 1989;139:682-87). As increased lung water also can cause neonatal disturbances, the present study was undertaken to study the effects of oxygen on lung hyaluronan and lung water in preterm rabbit pups. Some pups were kept in oxygen while controls were kept in air. Pups were sacrificed and lungs were taken at ages 2-7 days after birth. The water content was measured as wet/dry weight, and hyaluronan with HA 50 (Pharmacia).
Results: In pups breathing air lung water content decreased (p<0.001) during the first day after birth and then remained at a low level. In pups born 1(a) and 2(b) days before term and breathing oxygen, higher hyaluronan levels were seen at 7(a:n=7, p<0.1) and 6(b:n-=5, p<0.001) days after birth, than in control pups breathing air (a:n=7, b:n=7). The higher content of hyaluronan was accompanied by a higher (a:p<0.05, b:p<0.01) water content than in controls.
Conclusion: Lung hyaluronan and lung water increase in preterm rabbit pups during oxygen exposure.
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Johnsson, H., Sedin, G., Jonzon, A. et al. HYALURONAN AND WATER CONTENT IN LUNGS FROM RABBIT PUPS BORN PRETERH AND SUBSEQUENTLY KEPT IN AIR OR OXYGEN. Pediatr Res 32, 635 (1992). https://doi.org/10.1203/00006450-199211000-00182
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DOI: https://doi.org/10.1203/00006450-199211000-00182