Abstract
To understand the mechanism behind improved oxygenation after surfactant in infants with RDS we analysed changes in lung compliance (CL, ml/cmH2O), lung resistance (RL, cmH2O/l/s/cm), overdistention (C20/C1), FRC (ml) and oxygen need (FiO2). Data were collected serially in nine infants (CurosurfR two, ExosurfR seven) (BW: 1389 ± 540 g) prior to and post surfactant treatment. Lung mechanics were determined by a differential pressure transducer and pneumotachography (PEDSR). FRC was measured by a helium dilution technique (PANDAR) with correction for gas leakage. Ventilator settings (except FiO2) were if possible kept constant during the study. (Data given as mean±SEM).
Surfactant significantly increases FRC, while lung compliance and resistance (during mechanical breath) do not improve. The improved oxygenation after surfactant treatment is probably related to increased lung volume.
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Farstad, T., Bratlid, D. EFFECT OF INTRATRACHEAL INSTALLATION OF SURFACTANT OH LUNG FUNCTION AND FUNCTIONAL RESIDUAL CAPACITY (FRC) IN PREMATURE INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS). Pediatr Res 32, 634 (1992). https://doi.org/10.1203/00006450-199211000-00175
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DOI: https://doi.org/10.1203/00006450-199211000-00175