Abstract
Peripheral lymphocytes are not a classical target for 1,25D, but they may constitude a very accesible tissue for vitamin D receptor (VDR) study when activated. Lynphocyte VDR (LVDR) is indistinguishable from classical VDR (50 KDa; encoded by identical mRNA) being upregulated too. Chronic administration of PB increases DBP and VDR in a target tissue as can be the kidney, but does it affect LVDR levels?. Four groups of seven rats, control, PB, PB+D and vitamin D, were treated for 4 weeks. After that time all groups showed normal levels for blood Ca, Pi, Mg and Alk-pase. Receptor studies and plasma values of 25 and 1,25D were:
The blood volume of the rat only give opportunity to assess LVDR in two animals of each treated group. LVDR showed a clear upregulation by 1,25D higher blood levels, and reflect the changes operated in the kidney. In conclusion, VDR in activated peripheral lymphocytes may behave as that of classical target tissues. CAICYT pm: 89-0018.
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Moya, M., Ballester, I., Campello, M. et al. 1,25 DIHYDROXYVITAMIN D (1,25D) LYMPHOCYTE RECEPTORS REFLECT CHANCES IN VDR TARGET TISSUES INDUCED BY PHENORBARBITAL (PB) IN RATS. Pediatr Res 32, 629 (1992). https://doi.org/10.1203/00006450-199211000-00145
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DOI: https://doi.org/10.1203/00006450-199211000-00145