Abstract
Since glutamine (Gln) is considered a major fuel for small bowel (SB), extensive SB resection could alter whole body Gln metabolism in vivo. Very few data are available on Gln metabolism in infants. Eleven infants with extensive neonatal SB resection leading them with 35 ± 12 cm SB length and 4 controls were studied. During the post-absorptive state infants received primed continuous iinfusion of 1,5 mg/Kg/h L-[2-15N] Gln and 0,4 mg/Kg/h L [1-13C] leucine. From stable isotopes plasma enrichments were calculated : Gln and Leu fluxes (Ra Gln) (Ra Leu). The 2 inflow components of RaGln were calculated release from protein breakdown (B Gln) and de novo synthesis (D Gln):
Gln fluxes are reduced after SB resection, mainly due to reduced de novo synthesis. In controls, Gln and Leu fluxes are significantly higher than in adult respectively : 344 ± 47 and 88 ±12 μmol/Kg/h (Metabolism 1991, 49 : 42-4). Those differences reflect difference in protein turn over rate and protein accretion between adult and infants.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hankard, R., Goulet, O., Colomb, V. et al. NEONATAL SMALL INTESTINAL RESECTION IN INFANTS: STUDY OF GLUTAMINE METABOLISM USING STABLE ISOTOPE. Pediatr Res 32, 626 (1992). https://doi.org/10.1203/00006450-199211000-00131
Issue Date:
DOI: https://doi.org/10.1203/00006450-199211000-00131