Abstract
Large amounts of glucose have to be infused in infants with transient hyperinsulinism. The metabolism of the high glucose intake has not been determined. We studied glucose metabolism in an infant with transient hyperinsulinism without maternal diabetes. Gest. age 41 wks, birthweight 3475 g. Hypoglycemia was observed on day 1 (glucose 0,2 mmol/l with convulsions. Insulin levels decreased from 90 mU/l on day 1 to 7 on day 11. Glucose metabolism was measured by indirect caloriuetry (ID) and stable isotope technique (U - 13C glucose) on day 6 and 11.
Results
CHO int. = total carbohydrate intake, MR = metabolic rate, RQ = resp. quotient, CHO util. = carbohydrate utilization, measured by ID, Ra = rate of appearance of glucose, Glue. oxid. = glucose oxid. measured by U-13 C glucose, NOD = non-oxidative glue, disposal.
Conclusions: 1. Glucose oxidation was not increased despite high glucose intake. 2. Hypoglycemia is not due to increased oxidation but to non-oxidative disposal. 3. There is a high conversion of glucose into fat.
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Van Goudoever, J., Sulkers, E., Kalhan, S. et al. GLUCOSE METABOLISM IN A TERM INFANT WITH TRANSIENT HYPERINSULINISM. Pediatr Res 32, 617 (1992). https://doi.org/10.1203/00006450-199211000-00077
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DOI: https://doi.org/10.1203/00006450-199211000-00077