Abstract
Reliance is widely placed cn PCV Le indicate bleed transfusion requirements cf neonates, although poor overall correlation between PCV and RCM has been demonstrated (Lancet, i :882-4, 1986). The aim of this study was to investigate the relationship between PCV and RCM with increasing pcst-natal age (PNA) and with estimated baby tctal bleed volume (TBV).
Pre-transfusicn RCM and PCV were measured in 16 babies of 24 to 35 weeks gestation, receiving a total of 36 bleed transfusions. Circulatory RCM was estimated using dilution cf haemoglobin F by transfused red cells. TBV was calculated from the RCM divided by the measured PCV.
PCV correlated pocrly with RCM in 9 babies studied on 17 occasions in the first 5 days PNA (r=0.152). In 7 babies studied on 13 occasions after 10 days PNA, correlation was good (r=0.820). Correlation was intermediate (r=0.629), in 5 babies studied on 6 occasions on days 6-10. At all ages, correlation cf PCV with RCM was greatest in babies with a TBV in the range 70-90 ml/kg (r=0.827: n= 14), compared tc these with a TBV above or below these values (r=0.580: N=22).
In conclusion PCV is a particularly peer gauge cf RCM in preterm infants in the first 5 days of life and when total bleed volume is net in the range 70-90 ml/kg.
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Russell, A., Rivers, R. CORRELATION OF PACKED CELL VOLUME (PCV) WITH RED CELL MASS (RCM): VARIATION WITH POST-NATAL AGE AND BLOOD VOLUME IN PRETERM NEONATES. Pediatr Res 32, 616 (1992). https://doi.org/10.1203/00006450-199211000-00068
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DOI: https://doi.org/10.1203/00006450-199211000-00068