Abstract
Our study presents data on in vivo measurements of regional Tau concentrations in different stages of early human brain development. We used the method of short echotime 1H-spectroscopy in single volumes of 3.3cm3 for the in vivo assessment. 27 preterm (≥37wk) and 22 term newborns(≥38wk), all fed maternal milk, were examined by 1H-MRS either in cerebellum or cerebrum. In comparison age-corresponding autopsy tissue was examined by high performance liquid chromatography (HPLC).
Concentrations of Tau measured in vivo by 1H-MRS and in autopsy tissue by HPLC are comparable. In cerebellum Tau concentration increases from preterm to term newborns.
Cerebellar Tau concentrations measured in autopsy tissue of term newborns are significantly higher than cerebral Tau concentrations (p<0.05). The same tendency is observed in the in vivo 1H-MRS data.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hüppi, P., Fusch, C., Boesch, C. et al. TAURINE CONCENTRATIONS IN BRAIN OF PRETERM AND TERM NEWBORNS MEASURED BY IN VIVO 1H-MRS AND CHROMATOGRAPHY IN AUTOPSY TISSUE. Pediatr Res 32, 613 (1992). https://doi.org/10.1203/00006450-199211000-00050
Issue Date:
DOI: https://doi.org/10.1203/00006450-199211000-00050