Abstract
To determine the degree of sensitization against: cow's milk(CM) we investigated IgG-antibodies(ab) against CM proteins in a prospective study of differently fed infants assigned to 6 feeding groups.
(Br)Breastfed exclusively (at least 4 weeks)(n=166); (Br+HM)breast-fed, but initial supplement with a partly hydrolyzed whey/casein milk (n=66);(Br+HA2)breastfed, initial supplement with a highly hydrolyzed soy/collagen product(n=28);(Br+CM)breastfed.initial supplement with CM(n=58);(CM)only CM-formula(n=139); (HA2)fed with a highly hydrolyzed product for 2 months, followed by CM(n=45). CM-ab were determined by an indirect immunofluorescent test using a geometrical mean titer (gmt)for interpretation (Bürgin-Wolff, EJP 1980). Serum was taken during weaning 4 weeks after addition of CM or in the 4th iuonth(groups CM, HA2) and in the 2nd year, (all groups).
In ttie 1st year of life the lowest gmt values wore obtained in the groups(Br), (Br+HA1)and(Br+HA2), the highest in group(CM)and(Br+CM) without differences between atopic and non-atopic infants. In ttie 2nd year of life all values decreased except those in group(Br+HA1). Weaning after 3 months results in low gmt titers, whereas earlier weaning showed the highest titers in group(Br+CM)followed by(Br+HA1), (Br+HA2) arid (Br). If all results were plotted against the ages there was much overlap between symptomatic and asymptomatic infants. Only the few CM-fed, very young infants with chronic gastrointestinal(GI) CM-protein intolerance(CMPI) showed very high titers,which helped to confirm the diagnosis. All had a relapse during a CM-challenge. The diagnostic significance of IgG-CM-ab is limited to infants with chronic GI CMPI.
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Keller, K., Bürgin-Wolff, A. & Wirth, S. THE DIAGNOSTIC SIGNIFICANCE OF IGG-COW'S MILK ANTI BODIES-REEVALUATED. Pediatr Res 32, 611 (1992). https://doi.org/10.1203/00006450-199211000-00039
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DOI: https://doi.org/10.1203/00006450-199211000-00039