Abstract
We studied 4 patients with ambiguous genitalia characterized by microphallus, bifid scrotum, blind vagina and bilateral chriptorchidism. The patients were submitted to stimulation test with hCG (50-100) U/Kg × 4 doses in prepubertals and 6,000 U, i.m. in pubertals with dosage of T and DHT by RIA after extraction with organic solvent, celite column chromatography to isolate DHT. The results as compared to the prepubertal and pubertal control groups showed normal response of the test and subnormal of DHT with an increased relation T/DHT, characterizing 5-elpha reductase deficiency. Patients ware treated with i.m. exogenous testosterone for 2 months (125 mg IM every 30 days) in prepubertals, and 6 months (250 mg/week), and with 2.5% topic dihydrotestosterone (2.5 gr DHT in 100 gr cold cream) for 1 month in prepubers and for 6 months in intrapubers for the development of the penis.
We concluded that the exogenous administration of T or DHT may induce penis growth in masculine pseudchermaphroditism caused by 5-alpha-reductase deficiency.
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Mendoça, B., Arnhold, I., Vaconcelos, C. et al. 20 DIAGNOSIS AND TREATMENT OF 5-ALPHA-REDUCTASE DEFFICIENCY. Pediatr Res 32, 252 (1992). https://doi.org/10.1203/00006450-199208000-00043
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DOI: https://doi.org/10.1203/00006450-199208000-00043