Abstract
ABSTRACT: In lung-lavaged surfactant-deficient rabbits (n = 6) requiring artificial ventilation, porcine surfactant was instilled endotracheally. This resulted in improvement of lung function so that the animals could be weaned off artificial ventilation. The animals were killed 4½ h after surfactant administration and the porcine surfactant protein was localized in the lung with a MAb. We found surfactant protein in all lobes of the lung but the distribution was not homogeneous. Surfactant protein C was found in less than 15% of the alveolar spaces and in less than 1% of the bronchi.
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Oetomo, S., Ley, L., Curstedt, T. et al. Distribution of Endotracheally Instilled Surfactant Protein SP-C in Lung-Lavaged Rabbits. Pediatr Res 29, 178–181 (1991). https://doi.org/10.1203/00006450-199102000-00015
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DOI: https://doi.org/10.1203/00006450-199102000-00015