Abstract
Reoxygenation after perinatal asphyxia may induce injury through oxygen free radicals. To test if room air is as effective as 100% O2 in resuscitation, hypoxemia (PaO2 2.3-4.3 kPa) was induced in 20 newborn pigs (2-5 days) by ventilation with 8% O2 in N2. When systolic ABP reached 20 mmHg, the animals were randomly given either 21% O2 (group 1, n=9) or 100% O2 (gr.2, n=11) for 20 min followed by 21% in both groups. Mean duration of hypoxemia was 93 and 99 min. Mean (SD) values are shown. Controls (n=5) were stable.
There were no statistically significant differences.
Conclusion: 21% O2 is as efficient as 100% O2 for normalizing ABP, BE and HX after servere neonatal hypoxemia in pigs.
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Rootwelt, T., Moen, A. & Saugstad, O. 54 HYPOXEMIA AND REOXYGENATION WITH 21% OR 100% O2 IN NEWBORN PIGS. CHANGES IN ARTERIAL BLOOD PRESSURE (ABP), BASE EXCESS (BE) AND PLASMA HYPOXANTHINE (HX). Pediatr Res 30, 637 (1991). https://doi.org/10.1203/00006450-199112000-00084
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DOI: https://doi.org/10.1203/00006450-199112000-00084