Abstract
To evaluate the effect of resuscitation on brain damage hypoxemia (PaO2 2.3-4.3 kPa) was induced in 17 newborn pigs (2-5 days) by ventilation with 8% O2 in N2. When systolic blood pressure reached 20 mmHg, the animals were randomly given either 21% O2 or 100% O2 for 20 min followed by 21% in both groups. After 4 days the brains were perfusion-fixed in deep anesthesia. Blinded pathological examination assessed the damage on a 0 to 3 scale. Controls (n=5) showed no damage. Number of animals with damage and the mean (SD) degree of damage (including undamaged animals) are given.
The CAT damage was mainly anoxic, in the white matter/cortex it consisted mostly of small infarctions, while in the cerebellum the damage was a mixture. There were no statistically significant differences between the groups. We conclude that reoxygenation with room air gives no more brain damage than with 100 % oxygen.
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Rootwelt, T., Løberg, E., Moen, A. et al. 53 HYPOXEMIA AND REOXYGENATION WITH 21% OR 100% O2, IN NEWBORN PIGS. MORPHOLOGICAL ASSESSMENT OF THE BRAIN AFTER 4 DAYS. Pediatr Res 30, 637 (1991). https://doi.org/10.1203/00006450-199112000-00083
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DOI: https://doi.org/10.1203/00006450-199112000-00083