Abstract
Estimations of cerebral blood flow (CBF) were attempted by both 133Xe clearance and near infrared spectroscopy (NIRS) on 11 occasions in 9 infants (4 girls and 5 boys). The median (range) gestational age was 27 (26-29) weeks and postnatal age was 3 (1-10) days. All infants were receiving mechanical ventilation and cranial ultrasound or autopsy revealed that while 1 infant had no evidence of cerebral injury, 3 infants had intraparenchymal lesions, and 5 had intraventricular haemorrhage; 6 infants died.
In each study one estimation of CBF by 133Xe was attempted; the measurement was technically inadequate in 2 cases. Withlin 1-9 (median 5) hours 3-8 estimations by NIRS were made. 26/61 measurements were technically inadequate, but at least 2 were possible in every infant. Comparisons were thus possible on 9 occasions. 133Xe measurements ranged from 4.6-13.2 ml100g-1 min-1 and mean NIRS measurements ranged from 8.6-20.4 ml100g-1 min-1. The mean difference between the methods was 2.3, and the limits of agreement were -5.0 to + 9.7 ml100g-1 min-1.
Considering the different principles involved and the time gap between estimations, this study shows reasonable agreement between the methods.
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Bucher, HU., Edwards, A., Lipp, A. et al. 13 COMPARISON BETWEEN 133XENON CLEARANCE AND NEAR INFRARED SPECTROSCOPY FOR ESTIMATION OF CEREBRAL BLOOD FLOW. Pediatr Res 30, 630 (1991). https://doi.org/10.1203/00006450-199112000-00043
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DOI: https://doi.org/10.1203/00006450-199112000-00043