Abstract
Pulmonary vasoconstriction was induced in six pigs by a bolus infusion of xanthine oxidase (XU) 1 U/kg into the right atrium. Pulmonary pressure and blood flow were recorded and the pulmonary vascular resistance (PVR) calculated. The stable arachidonate acid metabolites T×B2 and 6 keto PgF1a measured at regular intervals. Another six animals were pretreated with d-Penicillamine (d-P), 50 mg/kg i.v. before XO administration. Results: The table shows relative increase from baseline values at maximum PVR, 25 minutes after XO was given. (±SD)
The study shows that d-P potently inhibits XO induced pulmonary vascular resistance and XO induced prostanoid synthesis. The biological action of this pharmacological agent is unknown, but the data suggest that d-P may be a cyclooxygenase inhibitor or an oxygen radical scavenger. Could d-Penicillamine be used in the treatment of pulmonary hypertension in the newborn?
* p< 0.05 ** p< 0.01 vs XO group.
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Oroszlán, G., Rud, J. & Saugstad, O. 172 D-PENICILLAMINE ATTENUATES OXYGEN RADICAL INDUCED PULMONARY HYPERTENSION IN PIGS. Pediatr Res 28, 305 (1990). https://doi.org/10.1203/00006450-199009000-00196
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DOI: https://doi.org/10.1203/00006450-199009000-00196