Abstract
We have previously reported changes in the sodium transport systems in red cell membranes (STS) of essential hyper tensive patients (EH) and in normotensive offspring os essential hypertensive parents (N-EH).
The purpose of this study was to evaluate the effects of a salt-restricted diet on STS in the above groups. Na:K pump activity (P), Na:K cotransport (Co), Na:Na countertransport (CTT), Na leak (L) and red blood cell Na content (Nai) were measured in 19 EH age x:29y and in 14 N-EH age x: 29y and in 14 N-EH x: 13y before and after 14 days on a salt restrictive diet.
Both groups showed a significant decrease of Nai (p<0.001) and a significant increase of Na:K pump activity and Na:K cotransport (p<0.001). A significant correlation (r:0.53 p<0.01) was found between the drop in Nai and the decrease in diastolic blood pressure. Sodium restricted diet had no effects on either CTT or leak.
Thus, sodium restriction restored Na:K pump activity and Na:K cotransport, to values comparable to control non hypertensive patients population.
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Gimenez, M., Simsolo, R. & Grunfeld, B. SODIUM TRANSPORT SYSTEMS IN RED CEIL MEMBRANES AND SALT-RESTRICTED DIET. Pediatr Res 26, 165 (1989). https://doi.org/10.1203/00006450-198908000-00036
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DOI: https://doi.org/10.1203/00006450-198908000-00036