Abstract
C. Jejuni/coli (CJC) infection was prospectively evaluated during a six month period in a cohort of 198 Chilean infants. Fecal samples for CJC cultures were obtained from all diarrheal episodes detected through twice-weekly home visits. Samples from paired asymptomatic infants were also obtained. Blood samples taken at admission and at the end of the protocol were analyzed for CJ polyvalent antibodies by ELISA to OMPs antigen. CJC was isolated from 33/299 (11%) diarrheal episodes and from 20/304 (7%) asymptomatic infants. High CJC illness/ infection ratio (p< 0.05) was found in infants bellow 9 mo. Serological data demonstrate significant polyvalent antibody titers to CJ in 27/89 (30%) serum samples. The lowest prevalence (4%) was observed among < 9 mo infants and the highest in > 15 mo (63%), (p< 0.01). Results from 36 infants analyzed through paired serum samples revealed a significant increase in the number of seropositive individuals (8% on admission to 50% at discharge, p<0,001). This change in the iimune status correlated with symptomatic infection in 9/18 infants and with asymptomatic infection in other two. The antibody rise found in the remaining 7 infants suggest that they had non documented asymptomatic CJ infections. This study stresses the impact of CJC associated diarrheal infections and also the high frequency in which asymptomatic contacts trigger the immune response in infants living in our setting.
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Fiqueroa, G., Galeno, H., Troncoso, M. et al. ENTERIC CAMPYLOBACTERIOSIS IN CHILEAN INFANTS EVALUATED BY CULTURE AND SEROLOGY. Pediatr Res 26, 164 (1989). https://doi.org/10.1203/00006450-198908000-00034
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DOI: https://doi.org/10.1203/00006450-198908000-00034