Abstract
ABSTRACT: Umbilical blood was collected immediately at birth (<30 s) in full-term infants after vaginal deliveries (n = 33) and elective cesarean sections (n = 11). Blood gases, plasma adenosine, hypoxanthine, and catecholamine concentrations were determined. In vaginally born infants the median arterial adenosine concentration was found to be 0.46 μM (range 0.13-2.06) and the venous 0.48 μM (0.09-1.62). These levels were significantly higher (p < 0.01) than in infants delivered by elective cesarean section; 0.16 μM (0.04-0.42) in the artery and 0.17 μM (0.02-0.56) in the vein. Vaginally born infants showed about a 4-fold higher level of umbilical arterial catecholamines than infants born by elective cesarean section. There was a strong inverse correlation between arterial hypoxanthine concentration and pH (r =-0.81, p < 0.01). It is suggested that increased adenosine release at vaginal delivery modulates the stress response elicited by the strong catecholamine surge and may furthermore exert protective effects in perinatal asphyxia.
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Irestedt, L., Dahlin, I., Hertzberg, T. et al. Adenosine Concentration in Umbilical Cord Blood of Newborn Infants after Vaginal Delivery and Cesarean Section. Pediatr Res 26, 106–108 (1989). https://doi.org/10.1203/00006450-198908000-00007
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DOI: https://doi.org/10.1203/00006450-198908000-00007
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