Abstract
Radioimmuno assay (RIA) IGF-I determinations using incstar (INC) extracted plasma and Nichols (NI) - whole plasma determinations were performed in plasma samples of 19 GHD and 21 NSD prior to initiation of somatotropin (recombinant GH, BioTechnology General (Israel) Ltd.) and 1, 4, 6, 16, 24, 32, 40 and 52 weeks post therapy.
INC RIA had a lower coefficient of variation, and a lower overlap between CGHD and controls, and smaller fluctuation in IGF-I levels. NSD group has an intermediate IGF-I levels between CGHD and controls IGF-I levels correlated better with pubertal stage than with growth response. HG effect on IGF-I was greater in CGHD than in NSD.
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Zadik, A., Altman, Y., Chen, M. et al. 114 GROWTH HORMONS (GH) INDUCED IGF-I PRODUCTION IN CLASSICAL GH DEFICIENCY (CGHD) AND IN NEUROSECRETORY- DYSFUNCTION (NSD). Pediatr Res 24, 536 (1988). https://doi.org/10.1203/00006450-198810000-00135
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DOI: https://doi.org/10.1203/00006450-198810000-00135