Abstract
Increasing doses of biosynthetic human growth hormone (B-hGH) were given subcutaneously to 7 GH deficient subjects for three 14 days periods (2, 4 and 6 IU/day at 20.00 h) followed by 14 days without GH therapy. At the end of each period they were hospitalized for blood sampling. A dose-dependent increase in serum GH and somatomedin-C (Sm-C) levels occurred. However, the time course of the serum Sm-C patterns showed a significant fall in the evening during absence of therapy, a significant increase following infections of 2 IU of B-hGH, and constant levels within normal range during treatment with 4 and 6 IU. Plasma glucose was within normal range, with lower fasting levels (at 04.00 h) when no GH was given. Breakfast induced a plasma glucose rise when GH was administered, but no rise without GH, and a dose-dependent increase in the post-prandial insulin response. GH therapy increased serum levels of free fatty acids (p < 0.05) and 3-OH-butyrate but had no significant impact on serum triglyceride and cholesterol. We conclude that serum Sm-C levels show consistent GH dose-dependence, and that a GH replacement dose of 2 IU/day (1.5 IU/m2/day) is insufficient to maintain normal diurnal levels. Furthermore, a GH independent diurnal variation in these patients is suggested, and finally it is demonstrated that this authentic GH preparation possesses diabetogenic and lipolytic actions.
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Jørgensen, J., Flyvjerg, A., Lauritzen, T. et al. 96 DOSE-RESPONSE STUDIES WITH BIOSYNTHETIC HUMAN GROWTH HORMONE IN GROWTH HORMONE DEFICIENT PATIENTS. Pediatr Res 24, 533 (1988). https://doi.org/10.1203/00006450-198810000-00117
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DOI: https://doi.org/10.1203/00006450-198810000-00117