Abstract
Total body irradiation (TBI) is used in preparation for BMI and in order to evaluate the course of growth and endocrine disturbances an extensive follow-up has been designed. 17 children, aged 2.4-17.8 years received BMI for ALL (n=14), AML (n=2) and CML (n=l). Median height SDS in 14 children below age 15 was at time of BMI +0.48 (range -1.42 to 1.60) and after 12 months +0.12 (-1.16 to 1.20) (p<0.05). Those followed for 24 (n=9) and 36 months (n=6) had no significant fall in height SDS. Serum somatomedin C in the 6 cases followed for 36 months was normal. Peak growth hormone values after clonidine showed great variation and the results were inconclusive. Primary hypothyroidism was found in one case and elevated TSH values in 3 with T4 in normal range. No evidence of TSH insufficiency was seen. In all 8 girls above 10 years ovarian insufficiency developed and all were in need of replacement therapy. Of 2 boys above 10 years one had subnormal serum testosterone and one had bilateral orchiectomy performed. 6 of 7 boys below 10 years had normal gonadotropin response to LHRH and one was hyperresponsive. No evidence of gonadotropin insufficiency was found. Although preliminary, our data show that growth retardation does not seem to be of major importance whereas gonadal deficiency is pronounced and thyroid deficiency may be frequent. More data are needed and a detailed and prolonged endocrine follow-up seems essential.
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Krabbe, S., Müller, J., Børch, K. et al. 58 EVALUATION OF GROWTH AND ENDOCRINE FUNCTIONS AFTER BONE MARROW TRANSPLANTATION (BMI) FOR MALIGNANCIES. Pediatr Res 24, 526 (1988). https://doi.org/10.1203/00006450-198810000-00079
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DOI: https://doi.org/10.1203/00006450-198810000-00079