Abstract
In a previous study we found that after two years or more post radiotherapy for a brain tumor (BT) all children investigated had a very low spontaneous GH-secretion. The aim was now to evaluate how soon after radiotherapy this GH-impairment occurrs.
For the last three years all prepubertal children (n=5) irradiated for a BT at our hospital have been studied every 6 months after irradiation with a 24h-GH profile immediately followed by a GHRH (1-29) test. Integrated 30 min samples over 24h were measured and analysed with Pulsar program.
Results: During 0,5 - 2 years post irradiation GH secretion in three children irradiated with 35-40 Gy to the hypothalamus, declined progressively whereas two children who had received 56 Gy showed a blunted secretion already at the first measurement.
After two years all children had a very low spontaneous GH-secretion; AUCb<100 mU/l and GH max < 14 rmi/l. GH-response after GHRH declined gradually in each child during the two years but remained >30 mU/l. The growth rate decreased in all children.
Conclusion: This first longitudinal study performed during the first two years after irradiation for a BT supports the previous hypothesis that if GH-secretion is to be evaluated the appropriate time is at two years post irradiation. Before this time GH-secretion is heterogenous, probably due to the dose of irradiation delivered.
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Lannering, B., Marky, I., Mellander, L. et al. 54 GH-INSUFFICIENCY DEVELOPES WITHIN TWO YEARS AFTER CRANIAL IRRADIATION FOR A BRAIN TUMOR. Pediatr Res 24, 526 (1988). https://doi.org/10.1203/00006450-198810000-00075
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DOI: https://doi.org/10.1203/00006450-198810000-00075