Abstract
Basal plasma GH levels and response to an injection of 1ug/kg of synthetic 1-44(NH2) GHRH (SANOFI RECHERCHE - Toulouse) were prospectively studied at day 3 postnatally in 5 small for gestational age twin babies (SGA) compared to their adequate for gestational co-twin (AGA) and in 10 idopathic single SGA babies compared to 6 single AGA, under conditions approved by the Ethic Committee of Univ.Cl.Bernard. Means basal plasma GH were higher in SGA than in AGA but statistically different only for single (p < 0.01). Mean peak GH response to GHRH was markedly increase in SGA compared to AGA in both twins (202 ± 34 versus 116 ± 49 ng/ml) (p < 0.05) and single (190 ± 45 versus 80 ± 63 ng/ml) (p < 0.01). 12 SGA retested at 1 month showed (compared to day 3) a decrease in basal, absolute increment and peak GH response to GHRH (p < 0.0 U. In 21 SGA as in 17 AGA serum IGF-1 was measured by RIA between 12 and 96 hours after birth. Mean serum IGF-1 value was significantly higher in SGA than in AGA (0.61 ± 0.29 versus 0.3 ± 0.14 U/ml) (p < 0.001). S-200 gel filtration chromatography of serum sample drawn at 3 days showed similar patterns in SGA and AGA. of both immunoreactive IGF-1 and 125-IGF-1 binding, with material eluting at 30-50 K and bearly detectable at 145 K (adult pattern) region. These data suggest post-natal functional hypersomatotropism in SGA compared to AGA babies. Regardless of the mechanism(s), this process could participate to the early post-natal catch up growth.
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Chatelain, P., Deiber, M., Naville, D. et al. 47 FUNCTIONAL HYPERSOMATOTROPISM IN SMALL FOR GESTATIONAL AGE NEWBORNS. Pediatr Res 24, 525 (1988). https://doi.org/10.1203/00006450-198810000-00068
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DOI: https://doi.org/10.1203/00006450-198810000-00068