Abstract
We have previously shown that twice daily sc GHRH therapy promotes growth in GH-deficient children (Lancet 1987;i:5-8), however this is not an optimal method of administering GHRH and the development of a long-acting preparation would be much more satisfactory. To investigate this possibility we have studied GH profiles during twice daily GHRH treatment and the sc infusion of GHRH. 4 children who grew on twice daily sc GHRH therapy (500ug) had 24-hour GH profiles (15min sampling) whilst on treatment and in 1 before therapy and in the others one month after finishing treatment. Two children have had overnight GH profiles (20min sampling) during sc infusion of two doses of GHRH (5 and 10ug/kg/hr) and placebo. The results demonstrate that in GH-deficient children twice daily GHRH increases pulse amplitude and AUC for GH but not always pulse frequency, a similar effect is seen during the sc infusion of GHRH. These results suggest that a depot preparation of GURH delivering 5ug/kg/hr would promote pulsatile GH release.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ross, R., Tsagarakis, S., Nhagafoong, L. et al. 43 Growth hormone profiles in GH-deficient children on and off twice daily sc GHRH therapy and during a sc infusion of GHRH. Pediatr Res 24, 524 (1988). https://doi.org/10.1203/00006450-198810000-00064
Issue Date:
DOI: https://doi.org/10.1203/00006450-198810000-00064