Abstract
Recently serum GH-BP has been shown to have identical N-terminal amino acid sequence as the tissue hGH receptor. Serum hGH levels and the specific binding activity of GH-BP (expressed as % of GH-BP activity of an adult reference serum = RSGH-BP) were estimated in 25 prepubertal children (19 M, 6 F, aged 6-11 yrs). When the results were related to height, 3 groups could be distinguished.
It is evident that GH-BP levels in children significantly correlated (r=0.83, p ≪ 0.001) with height SDS, but not with basal hGH levels or age. It is therefore possible that GH-BP presents a simple non-invasive tool to determine growth hormone activity.
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Silbergeld, A., Lazar, L., Eshet, R. et al. 42 SERUM GROWTH HORMONE BINDING PROTEIN (GH-BP) IN PRE-PUBERTAL CHILDREN IS CORRELATED WITH HEIGHT. Pediatr Res 24, 524 (1988). https://doi.org/10.1203/00006450-198810000-00063
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DOI: https://doi.org/10.1203/00006450-198810000-00063