Abstract
Turner mice (xo) and xx mice with the same genetic background were treated for a 6-month period with daily subcutaneous doses of 0.5 IU NorditropinR or placebo, starting at the age of 5 weeks to 5 months. The Turner mice which were treated with NorditropinR reached a significantly higher ultimate body weight (about 38g) and ultimate length (nose to tip of the tail - about 21.5cm) compared to the placebo-treated Turner mice (about 28g and 19cm). The body weight remained constant after cessation of treatment. There was no correlation between age at the start of treatment and ultimate weight or length.
Upon sacrifice it was found that the femoral and tibia bones from the NorditropinR-treated Turner mice were significantly longer compared to placebo mice. The ultimate weight and length of the NorditropinR-treated xx mice, as well as the length of their bones, were not significantly different from the comparable parameters in placebo-treated xx mice. Both xo and xx mice reached their ultimate weight significantly faster when they were treated with NorditropinR compared to placebo (means: 22.1 and 19.7 weeks respectively after start of dosing).
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Damm Jørgensen, K., Jensen, S. 38 EFFECT OF GROWTH HORMONE TREATMENT ON ULTIMATE WEIGHT AND LENGTH OF TURNER MICE. Pediatr Res 24, 523 (1988). https://doi.org/10.1203/00006450-198810000-00059
Issue Date:
DOI: https://doi.org/10.1203/00006450-198810000-00059