Abstract
Subjects with impaired nutritional status are known to have high hGH levels and very low IGF I levels. With a view to studying the regulation of the different molecular forms of IGF binding proteins (BPs), Western blotting was used to analyse the sera of 19 4-to 15-year-old children with coeliac disease before and/or during treatment, and to compare their BP profiles with those of hypopituitary (n=7) and obese (n=7) children of the same age. The untreated coeliac disease patients (n=14) were all stunted in height (m = -3.6 SD) and weight (m = -2.1 SD) and had high hGH (m =28 ng/ml) and low IGF (0.30 U/ml) levels. In 12, the electrophoretic profiles closely resembled those of the hypopituitary patients with significantly decreased 42- and 39K BPs (which are the subunits of the 150 K [IGF-BP] complex) and a strongly enhanced 34 K 8P. In the treated subjects (n=7), the clear resumption of growth (+ 8.2cm in 8 months) was accompanied by a slight rise in IGF levels and a gradual change in the BP profiles which became normal in only two out of the three patients on gluten-free diet over one year. In the obese cases, negligible GH levels accompanied normal IGF levels, normal 39- and 42K, and diminished 34K BPs. These findings indicate 1) that the amount of 39- and 42K BP in the serum is more closely linked to IGF than to GH levels and 2) that their slow rise in patients on a gluten-free diet may favour growth resumption by increasing the bioavailability of IGFs.
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Gourmelen, M., Hossenlopp, P., Cabrol, S. et al. 30 SERUM IGF BINDING PROTEINS ELECTROPHORETIC PROFILES IN CHILDREN WITH COELIAC DISEASE. Pediatr Res 24, 522 (1988). https://doi.org/10.1203/00006450-198810000-00051
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DOI: https://doi.org/10.1203/00006450-198810000-00051