Abstract
Hypercalcemia has been described in infants with CH before and after treatment with Thyroxine (T4). In a group of 25 infants, hypercalcemia during T4 therapy was related to vit D supplementation (in France 1200iu/d). To study further adequate vit D dosage to maintain normal Ca levels, 2 groups of infants were studied during the first 6 months of life. Group I (n=5) without and Group II (n=10) with 400 iu/d of vit D. Serum Ca (mg/dl +SEM) and 250HD were measured at diagnosis (<lmonth) before treatment, and at 2, 4 and 6 months of life.
In group I, Ca was normal and 25(OH)D was: 15+5, 7+4, 9+2 ng/ml at 2, 4 and 6 months. In 1 case however, hypocalcemia and low 25(OH)D occured at 3 months of age and necesssitated vit D administration. In group II, Ca was moderately elevated with a significant difference between the 2 groups at 4 months. 25(OH)D levels were 17+2, 21+6, 15+2 ng/ml at 2, 4, 6 months, within the normal range in France.
In conclusion: in infants with CH, low dosage of Vit D is associated with hypercalcemia whereas infants receiving no vit D are at risk of hypocalcemia. Vit D supplementation should be given with caution to infants with CH up to the 6th month of age and carefully controlled by serum Ca measurement.
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Léger, J., Tau, C., Garabedian, M. et al. 24 HYPERCALCEMIA IN INFANTS WITH CONGENITAL HYPOTHYROIDISM (CH) RECEIVING 400 iu/d Vit D. Pediatr Res 24, 521 (1988). https://doi.org/10.1203/00006450-198810000-00045
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DOI: https://doi.org/10.1203/00006450-198810000-00045