Abstract
In a district of an iodine-deficient area with an average goitre frequency of 4.7% (n=15 904) in the years 1976-1982 low BEI values (<4.0, ug%) were measured in 93 out of 154 (60.4%) newborns with goitre, a retarded bone age was evident in 58 out of 118 cases (49.2%). Following salt iodination (25mgKI/kn salt since 1983 and 32mg KIO3/kg since 1985) a reduction in goitre frequency from 3.4% in 1982 (n=2811) to 1.0% in 1985 (n=2656) and after introduction of an additional iodination of animal feed mineral mixtures in 1986 to 0.1% and 0,15% took place in 1986 and 1987, reap.(n=5337). Urinary iodine excretion increased in newborns without goitre from 10.6±6.6 in 1982 (n=38) to 45.3±36,ug/l(n=12) in 1987 duringthe 5th day of life, in mothers from 19.3±7 5th day of life, in mothers from 19.3 ± 7.4 ug/l (n=57) to 64.6-30 /ug/l (n=32) on the 5th day p.p. In mother's milk only a slight augmentation was measured on the 5th day p.p.(13.6±8.2/ug/l, n=57 to 19.2±7.6/ug/l, n=33). It is concluded that under the country-wide used iodination system the iodine supply to the fetus by pregnant mothers is sufficient to prevent newborn goitres and in this way transient hypothyroidism in the newborn age.
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Hesse, V., Rönnefarth, G., Sander, I. et al. 21 DRASTIC REDUCTION OF NEWBORN GOITRE FREQUENCY 2 YEARS AFTER IODINE PROPHYLAXIS IN THE TOWN OF JENA/DDR. Pediatr Res 24, 520 (1988). https://doi.org/10.1203/00006450-198810000-00042
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DOI: https://doi.org/10.1203/00006450-198810000-00042