Abstract
ABSTRACT: A transfontanellar range-gated ultrasound Doppler technique for recording blood flow velocity in an artery on the base of the skull was validated in eight anesthetized newborn lambs during hypo-, normo-, and hypercarbia. Blood flow velocity was linearly related to from 20 to 80 mm Hg; mean blood flow velocity (Vmean) (r = 0.86, p < 0.001), peak systolic blood flow velocity (r 0.83, p < 0.001), and end-diastolic blood flow velocity (r 0.87, p < 0.001). Vmean changed 2.0% per mm Hg of . A linear relationship was demonstrated between brain blood flow (BBF), as determined by the microsphere method, and (r = 0.91, p < 0.001), with BBF changing 3.6%/mm Hg of . Blood flow velocity was linearly related to BBF in the range studied; Vmean (r = 0.89, p < 0.001), peak systolic blood flow velocity (r = 0.87, p < 0.001), and end-diastolic blood flow velocity (r = 0.87, p < 0.001). However, Vmean predicted only approximately 55% of the change in BBF, which suggests a concomitant change in the cross-sectional area of the artery being studied. Despite this limitation, these data suggest that blood flow velocity, recorded by a transfontanellar range-gated Doppler technique from one of the two main arteries perfusing the brain, provides qualitative information on changes in BBF.
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Sonesson, SE., Herin, P. Intracranial Arterial Blood Flow Velocity and Brain Blood Flow during Hypocarbia and Hypercarbia in Newborn Lambs: A Validation of Range-Gated Doppler Ultrasound Flow Velocimetry. Pediatr Res 24, 423–426 (1988). https://doi.org/10.1203/00006450-198810000-00001
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DOI: https://doi.org/10.1203/00006450-198810000-00001
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