Abstract
Growth retardation in juvenile patients with Crohn's disease is only diagnosed retrospectively by growth rate measurements, however treatment requires early detection. In order to evaluate parameters useful to predict growth retardation we prospectively followed 26 juvenile patients and estimated standard deviation score of growth velocity (SDS-G), of weight gain (SDS-W), Best activity index (Al), and serum levels of a-1-glycoprotein (GP) and RIA-IGF-1/SmC.
Age corrected IGF-1/SmC levels were correlated to growth velocity (r=0.51). There was no relation to AI, GP and weight changes in these and a group of 17 adult patients (r-values:0.05 to 0.3). Specificity and sensitivity of these parameters possibly indicating growth retardation (<-0.3 SDS-G corrected to bone age) were calculated at the beginning (b) and the end (e) of the observation periods of 6-12 months:
IGF-1/SmC levels appear to be a superior index of growth retardation compared to the other parameters tested. Sensitivity and specificity could be increase to >0.9 and >0.8 respectively by selecting a SDS-G cutoff <-0.1, however calculation was limited by the small number of patients (n=5).
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Nützenadel, W., Koller, A. & Heinrich, U. 94 DO IFG-1/SMS SERUM LEVELS REFLECT IMPAIRED GROWTH IN CROHN'S DISEASE?. Pediatr Res 24, 420 (1988). https://doi.org/10.1203/00006450-198809000-00117
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DOI: https://doi.org/10.1203/00006450-198809000-00117