Abstract
It was reported that Campylobacter pyloridis colonization of gastric mucosa is responsible for active chronic gastritis and is also etiologically related to peptic ulceration.
According to Marshall a very specific and of high diagnostic value is CLO-test, designed to detect the urease enzyme of Campylobacter pyloridis.
The aim of the study was to determine the incidence of the Campylobacter pyloridis infection in children with upper gastrointestinal symptoms.
Material and methods
35 children, 14 girls and 21 boys, aged 8 - 18 y. mean age 14, were included in the study. After an overnight fast endoscopy using Olympus GIF P2 instrument without any premedication vas performed. Biopsies were assessed from the antral epithelium for CLO-test and histological examination.
Results
8 children had duodenal ulcer, 2 ulcer-related deformation of duodenal bulb, 9 gastritis, 16 were without pathology. Of these 16 were CLO-positive and 19 CLO-negative. Active duodenal ulcer and gastritis patients had a high incidence of Campylobacter pyloridis infection: 75 and 78% respectively, 10 CLO-positive patients (5 with ulcer and 5 with gastritis) received DE Nol (Gist Brocades) for 4 weeks, what significantly reduced the incidence of Campylobacter colonization: from 100% to 30%
Conclusions:
1. Campylobacter pyloridis infection is remarkably associated with chronic peptic disorders in children.
2. De Nol eradicates Campylobacter pyloridis from the antrum of children with duodenal ulcer and gastritis in a significant number of cases.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Socha, J., Celińska-cedro, D., Teisseye, M. et al. 69 CAMPYLOBACTER PYLORIDIS IN CHILDREN. Pediatr Res 24, 416 (1988). https://doi.org/10.1203/00006450-198809000-00092
Issue Date:
DOI: https://doi.org/10.1203/00006450-198809000-00092