Abstract
The levels of plasma lactoferrin in response to endotoxin and Escherichia coli infusion in piglets were studied to give exact time relation of plasma lactoferrin increase in relation to start of endotoxin and Eschericha coli infusion. Swine lactoferrin was determined by a new new enzyme linked immunoassay. In 13 piglets there was a ten-fold increase of plasma lactoferrin concentrations 2 hrs after the start of 0.25 mg/kg/2hrs endotoxin intravenous infusion. The initial rise was 3.4 mg/l/hr, thereafter it levelled off. Fourteen piglets, receiving a bolus of 1011 Escherichia coli intravenously, had a twenty-fold increase of plasma lactoferrin concentrations, amounting to 6-9 mg/l/hr. Fourteen piglets receiving the same bolus of Escherica coli intraperitoneally had an increase of 0.5 mg/l/hr.
These data indicate that plasma lactoferrin was an immediate marker of septiomemia and endotoxemia giving rise to twenty-folds increments of plasma lactoferrin within 2 hrs.
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131: PLASMA LACTOFERRIN IN PIGS. AN EVALUATION OF LACTOFERRIN AS A PARAMETER OF SEPTICAEMIA. Pediatr Res 24, 282 (1988). https://doi.org/10.1203/00006450-198808000-00156
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DOI: https://doi.org/10.1203/00006450-198808000-00156