Abstract
Acute imbalance between elastase (el) and α1-proteinase inhibitor (α1-Pi) may contribute in RDS and BPD; persistant imbalance in PV of VLBW infants has not been adreesed. Weekly (4-8 wks) serum (S) and bronchoalveolar (Bal) samplee were taken in 14 VLBW infants ventilated from birth: 9 had BPD (5 RDS, A others); 5 controls had no BPD (apneas). G.A. and B.W. were similar ((29.8-29.8 wks; 1180-1104 g). α1-Pi,α2-macroglobulin (α2-M), albumin (Alb) were measured in S and Bal by immunonephelometry, free el-activity by SAPNA in Bal. S and Bal results were similar at all times in controls and were pooled. Statistical study:ANOVA;*:p<0.05;**;p<0.25).
These results suggest a local destruction of α1-Pi and α2-M, and a persistant imbalance (increased ol/α1-Pi molar ratio).
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Walti, H., Saugier, P., Gerbault, L. et al. 111: ELASTASE-PROTEINASE INHIBITOR IMBALANCE IN PROLONGED VENTILATION (PV) OF VLBW INFANTS BPD. Pediatr Res 24, 279 (1988). https://doi.org/10.1203/00006450-198808000-00136
Issue Date:
DOI: https://doi.org/10.1203/00006450-198808000-00136