Abstract
We hypothesized that treatment of anemia by packed RBC transfusion in preterm infants will increase the mean inspiratory flow. Pulmonary mechanics were studied using an esophageal balloon and mask during the quiet state in 10 preterm anemic infants (Hct- 28±3) with a mean GA 29.2±2.4 wks at a postnatal age of 42±21 days, before and after (16 hrs) transfusion with 10 cc/kg of packed cells.
These results indicate that there is a significant deterioration in lung compliance, after transfusion. The increase in inspiratory impedance may have blunted the anticipated rise in mean inspiratory flow. Whether these changes are related to the volume of blood infused, remains to be determined.
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Sasidharan, P., Heimler, R. & Pelegano, J. 109: POST-TRANSFUSION DETERIORATION OF PULMONARY FUNCTION IN PRETERM INFANTS. Pediatr Res 24, 279 (1988). https://doi.org/10.1203/00006450-198808000-00134
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DOI: https://doi.org/10.1203/00006450-198808000-00134