Abstract
Loss of autoregulation of cerebral blood flow (CBF) under halothane-anesthesia has been shown in cats and monkeys. In human adults halothane enhances CBF. However, there are no data about the impact of halothane-anesthesia CBF in infancy. We measured changes of mean blood flow velocity of the right internal carotid artery (MBFV) by transfontanellar Doppler to estimate changes of CBF with induction of anesthesia by halothane 1.5 %. TcpCO2 was kept constant. Mean arterial blood pressure (MABP) was measured oscillometrically. Our study collective consisted of 9 infants (age 15-80, body weight 2.0-5.6 kg) undergoing minor operations. Results (median, range):
Conclusion: Narcotic doses of halothane may impair cerebral perfusion in young infants.
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Jorch, G., Reinhold, P., Woyke, H. et al. 103: IMPACT OF HALOTHANE-ANESTHESIA ON CEREBRAL CIRCULATION IN INFANCY. Pediatr Res 24, 277 (1988). https://doi.org/10.1203/00006450-198808000-00128
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DOI: https://doi.org/10.1203/00006450-198808000-00128