Abstract
The question of whether B enters the brain unbound or bound to A is of interest because bound B may not be toxic. We have studied the entry of 3H-B and 125I-A during C, D (sulfisoxazole 50mg/kg), HC (PCO2 18-21 kPa, pH 6.9), and HO (serum osmolality 400mosm/l) conditions. B and A entry were studied in two separate subsets of rats to avoid problems with spectral overlap of the isotopes. Hyperbilirubinemia was created by infusing B for 1hr, while 125I-A was given as a bolus dose at the start of the infusion period. Crude values for brain B and A were corrected for substance remaining intravascularly. Under C and D conditions, B enters the brain unaccompanied by A, i.e. unbound. Under HC, B enters the brain primarily unbound, but some may be A-bound. The increased entry of unbound B during HC may be due to increased blood flow. Under HO, B appears to enter the brain primarily bound to A.
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Hansen, T., øyasæter, S., Stiris, T. et al. 97: DIFFERENT MECHANISMS OF ENTRY OF BILIRUBIN (B) AND ALBUMIN (A) INTO YOUNG RAT BRAIN DURING CONTROL (C), DISPLACER (D), HYPERCARBIC (HC), AND HYPEROSMOLAR (HO) CONDITIONS. Pediatr Res 24, 277 (1988). https://doi.org/10.1203/00006450-198808000-00123
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DOI: https://doi.org/10.1203/00006450-198808000-00123