Abstract
ABSTRACT. The functional activity of naturally acquired IgG and IgM with specificity for the capsular polysaccharide of type III, group B Streptococcus (III-GBS) was compared. Sera collected during convalescence from 14 infants who had developed specific antibodies following III-GBS infection were employed for separation of IgG from IgM by ion-exchange chromatography. Bactericidal killing of III-GBS was similar for IgG- and IgM-rich samples (37 and 42%, respectively) in reactions containing a mean of 1.0 or 1.9 μg/ml of III-GBS specific IgG or IgM antibody. Purified IgA lacked opsonophagocytic activity for III-GBS. These results indicate that III-GBS-specific IgG and IgM antibodies in infant sera promote opsonophagocytosis at low concentrations, and that their functional capacity is comparable.
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Campbell, J., Baker, C., Metzger, T. et al. Functional Activity of Class-Specific Antibodies to Type III, Group B Streptococcus. Pediatr Res 23, 31–34 (1988). https://doi.org/10.1203/00006450-198801000-00007
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DOI: https://doi.org/10.1203/00006450-198801000-00007