Abstract
Urinary albumin excretion was evaluated in 43 type 1 diabetic children (27 females), aged 8.2 to 22.1 yr with duration of diabetes > 3 yr; the patients were divided into two groups according to their HbA1c: HbA1c < 8.0% (group A: n. 25) or HbA1c > 11% (group B: n. 18); 43 healthy sex and age-matched subjects served as controls. Three overnight urine collections were used to calculate the AER, basing on albumin concentration, urine volume and collecting time. The median values for AER in overnight urine were 5.1 μg/min in group A (range 1.8-13.7) and 16.3 μg/min in group B (range 5.2 - 83.7)(p < 0.001). In spite of up to 10 yr duration of diabetes, none of the group-A patients had AER above 15 μg/min; no difference in AER was observed between the low HbA1c group and the controls. After 12 months of improved metabolic control (HbA1c to < 8%), 8 of the children of group B showed normal overnight AER. Thus, a large percentage of poorly controlled diabetic children has AER > 15 μg/min regardless of diabetic duration; these findings question the value of using moderately elevated AER as a marker for the later development of nephropathy.
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Chiarelli, F., Lapenna, G., Manfra, T. et al. 77 ALBUMIN EXCRETION RATE (AER) IN DIABETIC CHILDREN AND ITS RELATION TO METABOLIC CONTROL. Pediatr Res 24, 273 (1988). https://doi.org/10.1203/00006450-198808000-00103
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DOI: https://doi.org/10.1203/00006450-198808000-00103
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