Abstract
Very fey data are reported od tie incidence of autoantibodies (SA) in normal children. He have studied the incidence of 14 AA in a total of 268 apparently normal children (151 males and 117 females; age range: 2 months-14 years with a homogeneous distribution for each year of age). Antinuclear (ANA), anti-mithocondrial (HA), anti-ribosomal (ARA), anti-smooth muscle (SMA), anti-reticulin (HA), anti-double stranded DBA (dsDNA), anti-gastric parietal cell (PCA), anti-intestinal epithelial cell (IECA), antiliver/kidney microsomal (LKH), islet cell (ICA-IgG) and complement-fising islet cell ICP-ICA) antibodies were determined by indirect iBiunofluorescence; rheumatoid factor (RF) was detected by lates agglutination; anti-thyroglobulin (IgA) and anti-thyroid microsomal antigen (MsA) antibodies were detected by passive hemagglutination. U children (22 sales and 19 females) were positive for at least one AA, usually in low titer; two were positive for 2 AA. None of these children had a personal or family history of autoimmune diseases. The percentage of children positive for each AA was as follows: ANA 3%, SMA 2.6%, RA 2.6%, MA 1.1%, BF 0.6%, ARA 0.6%, PCA 5,2%, HsA 1.3%. Anti-dsDNA, IECA, LKH, ICA, CF-ICA and TgA were not detected in any sera. Fifteen of the 41 positive children were checked again for the presence of AA two years later; 6 (40%) were still positive, always for the saw AA, without major differences in titer. Our results show that the incidence of serum AA in normal children is similar to that reported in young adults. In more than half this positivity appears to be a transient phenouenon; the possible significance of the persistence of AA in some apparently normal children remains to be defined.
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Martini, A., Zanaboni, L., Ravelli, A. et al. 62 INCIIEICB OF AUTOANTIBODIES IF NOBMAL CHILDREN. Pediatr Res 24, 271 (1988). https://doi.org/10.1203/00006450-198808000-00088
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DOI: https://doi.org/10.1203/00006450-198808000-00088
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