Abstract
The knowledge of the trace element requirements of infants fed a phenylalanine restricted diet due to PKU ( Phenylketonuria ) is very limited. We studied 3 infants with PKU under their diet ( Milupa PKU 1 ) longitudinally in balance studies ( ≥ 72 hours ) under home conditions at the age of 2, 5, 8, 12, 16 weeks. Mn, Cu, Fe concentrations in diet, feces and urine were determined by Atomic Absorption Spectroscopy. Median concentrations found in the final diet were 1.7 mg/l Cu, 6 mg/l Fe, 0.5 mg/l Mn. The comparison of the retention rates with the data of 10 healthy breast-fed ( BF ) infants studied before ( s. table (showed a higher range of Mn and Fe retention.
The median absolute retention of copper from PKU-diet exceeded that from human milk. Iron supplementation leading to median retentions sixfold the retentions from human milk seems to be unnecessary. Manganese supplementation should be avoided as neither symptoms of deficiency in formula-fed infants have been described nor possible side effects have been excluded.
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Sievers, E., Oldigs, HD., Dörner, K. et al. 58 TRACE ELEMENT OVERLOAD IN PKU - DIET?. Pediatr Res 24, 270 (1988). https://doi.org/10.1203/00006450-198808000-00084
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DOI: https://doi.org/10.1203/00006450-198808000-00084
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